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Products > Oral Steroid > > Oral steroid Anastrozole Arimidex 50mg/ml for Antiestrogen
Oral steroid Anastrozole Arimidex 50mg/ml for Antiestrogen
Oral steroid Anastrozole Arimidex 50mg/ml for Antiestrogen
Product name : Oral steroid Anastrozole Arimidex 50mg/ml for Antiestrogen
Item : Anastrozole
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  Details:

Arimidex is an aromatase-inhibiting drug approved for treatment of breast cancer after surgery, as well as for metastasis in both pre and post-menopausal women. The severity of breast cancer is increased by estrogen, as sex hormones cause hyperplasia, and differentiation at estrogen receptor sites. Arimidex works by inhibiting the synthesis of estrogen.

 

Anastrozole

Alias: Arimidex
CAS No: 120511-73-1
MF: C17H19N5
MW: 293.37
Purity: 99%min
Appearance: White crystalline powder.
Usage: An aromatase inhibitor. Used as an antineoplastic raw materials.
Potent selective triazole aromatase inhibitors, can inhibit the cytochrome P-450 aromatase enzyme which depends blocking the biosynthesis of estrogen, and estrogen to stimulate breast cancer cell growth factors. Treatment of breast cancer, especially for those with hormone relapse after adjuvant therapy after menopause for women with advanced breast cancer.

 

Description:

 

The drug is appropriately used when using substantial amounts of aromatizing steroids, or when one is prone to gynecomastia and using moderate amounts of such steroids. Arimidex does not have the side effects of aminoglutethimide (Cytadren) and can achieve a high degree of estrogen blockade, much moreso than Cytadren. It is possible to reduce estrogen too much with Arimidex, and for this reason blood tests, or less preferably salivary tests, should be taken after the first week of use to determine if the dosing is correct.

 

Application:

 

Usage in men:
Anastrozole has been tested for reducing estrogens, including estradiol, in men. Excess estradiol in men can cause benign prostatic hyperplasia, gynecomastia, and symptoms of hypogonadism. It can also contribute to increased risk of stroke, heart attack, chronic inflammation, prostate enlargement and prostate cancer.Some athletes and body builders will also use anastrozole as a part of their steroid cycle to reduce and prevent symptoms of excess estrogens; gynecomastia and water retention. Study data suggests dosages of 0.5 mg to 1 mg a day reduce serum estradiol approx. 50% in men, which differs in postmenopausal women.
Usage in children:
Anastrozole may be used off-label in children with precocious puberty, or children with pubertal gynecomastia.Following the onset of puberty, the epiphyseal plate begins to close due to an increased amount of estrogen production escaping local metabolism and spreading to the circulatory system. It is shown to help slow this process, and increase adult height prediction in adolescent males treated with protein-based peptide hormones for the treatment of growth hormone deficiency.
 

Specification:
    


Items
StandardResults
DescriptionWhite crystalline powderComplies
IdentificationIR
HPLC
Reactive
Conform with standard IR
Conform with standard HPLC
Conform
SolubilityFreely soluble 
in methanol,
acetone,ethanol 
and tetrahydrofuran.
And very soluble in 
acetonitrile
Complies
Total Impuritymax.0.5%0.18%
Total Unspecified Impuritymax. 0.2%0.08%
Individual unspecified 
impurlty
max. 0.1%0.05%
Related compound Bmax. 0.2%0.07%
Related compound Cmax. 0.2%0.04%
Related compound Dmax. 0.1%0.05%
Related compound Emax. 0.1%0.06%
Limit of cyclohexanemax. 0.08%ND
Limit of ethylacetatemax. 0.1%0.07%
Melting point81.0~84.0oC82.5~83.2oC
Watermax. 0.3%0.21%
Residue on ignitionmax. 0.1%0.07%
Heavy Metalsmax.0.001%Complies
Assay(HPLC)98.0%~102.0%99.8%
StorageCool and dry
ConclusionIt complies to USP32 .


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